[Swiftwater Gazette] antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
kroposki at att.net
Wed Aug 31 15:17:11 EDT 2016
Theantibody aducanumab reduces Aβ plaques inAlzheimer’s disease
Alzheimer’sdisease (AD) is characterized by deposition of amyloid-β (Aβ)
plaques and neurofibrillary tangles in the brain, accompanied bysynaptic
dysfunction and neurodegeneration. Antibody-basedimmunotherapy
against Aβ to trigger its clearance or mitigate itsneurotoxicity has so far
been unsuccessful. Here we report thegeneration of aducanumab, a
human monoclonal antibody thatselectively targets aggregated Aβ.
Resultsjustify further development of aducanumab for the treatment
of AD.Should the slowing of clinical decline be confirmed in ongoing
phase3 clinical trials, it would provide compelling support for the
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